Collections
NEWS - Timely articles written from a journalistic perspective on hot areas in the bone field.
Investigations of Serotonin and Bone: What Might the Future Look Like?
Neil A. Andrews
Now that a series of influential papers on serotonin and bone have been published in the scientific literature, the bone field can expect to see a substantial increase in research activity in this area -- so say experts with a long-standing interest in the effects of serotonin, and SSRIs, on the skeleton. This news article features interviews with these experts, who share their views on the shape future investigations might take.
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PERSPECTIVES - Insightful, thematic reviews of key topics on both the basic science and clinical sides.
FGF23: Phosphate Metabolism and Beyond
Seiji Fukumoto
In his review article, Dr. Fukumoto summarizes current knowledge of FGF23, as well as areas in need of further research. Topics discussed include the identification and biological function of FGF23; the role of FGF23 as a pathological humoral factor in hypophosphatemic diseases; the role of FGF23 as a physiological humoral factor; FGF23 and chronic kidney disease-mineral and bone disorder; and FGF23 and cardiovascular risk and mortality.
[Abstract] [Full Text] [PDF]
COMMENTARIES - Analyses of specific pathbreaking papers appearing in all of the major scientific and medical journals.
Costimulatory Blockade to Prevent Osteoclastogenesis, Inflammation, or Both?
Julia F. Charles and Mary C. Nakamura
The authors analyze a recent paper in The Journal of Experimental Medicine by Joyce-Shaikh et al. focusing on a role for myeloid DAP-12-associating lectin (MDL)-1 in synovial inflammation and bony destruction in inflammatory arthritis. Will the MDL-1 receptor be a useful therapeutic target?
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MEETING REPORTS - Comprehensive examinations of new findings presented at the major bone meetings.
The Interface Between Nerves, Muscles and Bone: Meeting Report from the 7th International Workshop on Musculoskeletal and Neuronal Interactions
Jörn Rittweger and Frank Rauch
The authors discuss the most recent bi-annual meeting hosted by ISMNI in May. Topics covered include mechanography, new uses of pQCT, and whole body vibration.
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NOT TO BE MISSED - Annotations, written by the IBMS BoneKEy editors, on the most important articles published in the literature each month.
Manolagas SC. From estrogen-centric to aging and oxidative stress: a revised perspective of the pathogenesis of osteoporosis. Endocr Rev. 2010 Jun;31(3):266-300.
The most enduring theory of aging stipulates that oxidative stress resulting from mitochondrial metabolism and the resulting increase in intracellular reactive oxygen species (ROS) is the major determinant of aging and lifespan. This review provides ample evidence that the age-related increase in ROS is...
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ARTICLES - Unique content covering special topics, such as new clinical guidelines.
The Epidemiology of Osteoporosis in Asia
Edith M. Lau
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ELECTRONIC LETTERS TO THE EDITOR - Comments submitted by readers in response to original content published on BoneKEy.
All Clinicians Are Bayesians
Robert S. Fredericks
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